Studies

Cardiovascular Inflammation Reduction Trial (CIRT)

We are seeking men and women age 18 and over.

What is the goal of CIRT?

If you have had a prior heart attack, your risk of having a second heart attack or sufferingg a stroke is high, even if your doctor has you on an aggressive treatment plan. In part, this increased risk is related to high levels of inflammation in your blood vessels. The main goal of the Cardiovascular Inflammation Reduction Trial (CIRT) is to see if reducing inflammation can lower your risk of having a secod heart attack, a stroke, or dying from heart disease.

Why test Low-Dose Methotrexate (LDM)?

Low-dose methotrexate (LDM) is a very common anti-inflammatory drug taken by millions of older individuals who have severe arthritis. LDM has been in wide clinical use for nearly 40 years, and doctors have noticed that people with arthritis taking LDM seem to have lower rates of heart disease. However, it is not known if LDM will prevent heart attacks and stroke among people who do not have arthritis, but like you, have had a prior heart attack.

Who is involved in CIRT?

CIRT is funded by the National Heart, Lung, and Blood Institute, and is being conducted by physicians at specially selected sites across the United States and Canada. Each of these physicians has been screened to participate in CIRT, understands the trial design, and has been trained in all trial procedures. 

What is a randomized trial?

CIRT is a randomized trial. That means that half of all participants will receive active study drug and half will receive inactive study drug known as placebo. When completed, CIRT will tell us whether or not those who received the active treatment had fewer heart attacks and stroke compared to those who received the placebo. If successful, a positive outcome from CIRT will benefit all heart attack patients as they will have a potentially new way to treat their disease in the future. Your participation will thus be important for future patients.

Am I eligible to participate?

You may be eligible to participate in CIRT if you have had a heart attack in the past 5 years and have been diagnosed with either diabetes or a condition called "metobolic syndrome" which puts you at high risk for developing diabetes. Your physician can help you decide if CIRT is right for you. 

What can I expect if I participate?

If you choose to participate in CIRT, you will be followed for up to 5 years. During that period, you will receive all of your usual medical care. In addition, you will also receive special calendar packs which contain the study medications and you will be closely monitored by the study team for safety and for clinical events that may occur. At a minimum, you will see the study team for a brief office visit every 4 months for the duration of the trial. There is no expense to you for these extra visits to see the study team. 

Interested in a study?
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